H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine -Lyase

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Duodenal acidification stimulates gastric H2S release through upregulating mRNA expression of cystathionine gamma lyase

Introduction: It has been reported the alkaline response of pancreas to duodenal acidification is partly mediated through duodenal release of H2S, but till now the effect of duodenal acidification on gastric H2S release has not been investigated. Therefore, the present study designed to evaluate the effects of duodenal acidification on gastric H2S release and level of mRNA expression of cys...

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Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis

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Hydrogen sulfide (H2S) is the most recently characterized autocrine/paracrine messenger implicated in the control of vascular tone. A series of coherent observations now document that this gas is a strong vasorelaxant and a determinant of blood pressure in experimental models. Targeted deletion of the gene encoding cystathionine-lyase (CSE). CSE, a key enzyme for H2S biosynthesis, reduces serum...

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duodenal acidification stimulates gastric h2s release through upregulating mrna expression of cystathionine gamma lyase

introduction: it has been reported the alkaline response of pancreas to duodenal acidification is partly mediated through duodenal release of h2s, but till now the effect of duodenal acidification on gastric h2s release has not been investigated. therefore, the present study designed to evaluate the effects of duodenal acidification on gastric h2s release and level of mrna expression of cystath...

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ژورنال

عنوان ژورنال: Science

سال: 2008

ISSN: 0036-8075,1095-9203

DOI: 10.1126/science.1162667